Our research
Research updates
A record of what happened, corrections included — not a record of what we hope will happen.
What counts as an update here
Something that actually happened: a source read, an analysis plan fixed, a parameter recorded, a result validated, an error of ours corrected. Not intentions, not plans, not milestones we hope to reach. Corrections of our own earlier statements are posted with the same prominence as findings — a project that only publishes its advances is not keeping a record, it is running a campaign.
Timeline
Still open
Carried forward until closed and dated:
- Read the sequence-feature annotation for UniProt Q05639 around residues 88–96 verbatim, and record what is annotated there. Until then no claim is made about residue 91 and the nucleotide site.
- Establish which experimentally determined eEF1A2 structures exist and in which nucleotide state, since this determines whether a GTP-state model is observed or built.
- Record the simulation run parameters — nucleotide state, force field, water and ion parameters, length, replicate count — without which the trajectory is not reproducible.
- Resolve journal and persistent identifiers for the cohort paper on which most of the D91N record rests, and read the published Correction to the largest genotype–phenotype study before quoting its figures.
- Find the primary biochemical characterisation of the recurrent variants rather than citing a review for it.
The same list, with the reasons each one matters, is on the D91N research page.